Buy Cheap Skytrofa (lonapegsomatropin-tcgd) 3mg For Sale. Skytrofa (lonapegsomatropin-tcgd) is a human growth hormone used once weekly for the treatment of pediatric growth hormone deficiency.
How does Skytrofa (lonapegsomatropin-tcgd) work?
Somatropin has been a standard of care to treat children with growth hormone deficiency. However, the daily administration is burdensome. Somatropin binds to the growth hormone (GH) receptor in the cell membrane, leading to bone growth, muscle growth and the breakdown of fat.
The active ingredient in Skytrofa, lonapegsomatropin, is a medicine that consists of three ingredients: the GH somatropin, an inert carrier, and a linker that connects somatropin and the carrier. The carrier has a protecting effect that minimizes excretion via the urine and breakdown of the hormone.
Skytrofa is designed to release somatropin at a specific rate so it can work similarly to GH that is normally produced by the body and to daily somatropin treatment.
Lonapegsomatropin, functioning as a prodrug of somatropin, undergoes autocleavage, releasing active somatropin from the methoxypolyethylene glycol carrier.
This compound binds to the growth hormone receptor, resulting in both direct effects and indirect effects mediated by insulin-like growth factor-1 (IGF-1).
The impact of somatropin includes stimulation of chondrocyte differentiation and proliferation, glucose release from the liver, protein synthesis, lipolysis, and direct tissue and metabolic effects.
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How is Skytrofa (lonapegsomatropin-tcgd) taken?
The standard dosage for treatment-naïve patients and patients switching from daily somatropin therapy is:
0.24 mg/kg body weight, given once-weekly via under the skin (subcutaneous) injection
The dose may be adjusted based on the child’s weight and insulin-like growth factor-1 (IGF-1) levels.
The injections are given into the abdomen, buttock, or thighs using the Skytrofa Auto-Injector.
It is important that you inform your doctor about all medicines you take, because Skytrofa (lonapegsomatropin-tcgd) may affect the way other medicines work, including glucocorticoids, oral estrogen, insulin and/or other hypoglycemic agents, and cytochrome P450-metabolized drugs.
Complete information about Skytrofa (lonapegsomatropin-tcgd) dosage and administration can be found in the official prescribing information listed in our references section
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